Hypoglycaemic Activity of Aloe Vera Barbadensis in Normal and Alloxan Induced Diabetic Rabbits

Authors

  • Awal Noor Khan Department of Agronomy, Faculty of Agriculture, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan Author
  • Rashid Khan Department of Basic Medical Sciences, Faculty of Pharmacy Gomal University, D. I. Khan, Khyber Pakhtunkhwa, Pakistan Author
  • Xue Li Collage of Land and Environment, Shenyang Agricultural University, Shenyang, China 11086 Author
  • Umar Khitab Saddozai Department of Agronomy, Faculty of Agriculture, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan Author
  • Haris Khan Gomal Center of Biochemistry and Biotechnology, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan Author
  • Muhammad Wasim Department of Medical Lab Technology, Faculty of Allied Health Sciences, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan Author
  • Babar Ali Department of Agronomy, Faculty of Agriculture, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan Author
  • Muhammad Nadeem Faculty of Veterinary and Animal Sciences, Gomal University, D.I. Khan, Khyber Pakhtunkhwa, Pakistan Author

DOI:

https://doi.org/10.64229/h3z9m964

Keywords:

Aloe Vera Barbadensis, Hypoglycaemic Activity, Alloxan-induced Diabetes, Diabetic Rabbit Model, Blood Glucose Regulation

Abstract

Diabetes mellitus is a chronic metabolic disorder marked by persistent hyperglycemia resulting from insufficient insulin secretion, impaired insulin action, or both. With its global prevalence on the rise, interest in plant-based therapeutics has increased due to their affordability and lower side-effect profile compared to conventional drugs. Aloe vera (Aloe barbadensis) is a medicinal plant known for its anti-inflammatory, antioxidant, and antidiabetic properties. This study aimed to evaluate the hypoglycemic effect of crude Aloe vera extract in normal and alloxan-induced diabetic rabbits. Eighteen healthy male rabbits were randomly assigned into three groups: Group I (Normal Control), Group II (Diabetic Control), and Group III (Diabetic Treated with Aloe vera). Diabetes was induced in Groups II and III using alloxan monohydrate (120 mg/kg body weight, i.p.). Group III received Aloe vera gel extract orally at a dose of 300 mg/kg daily for 21 days. Blood glucose levels were measured on days 0, 7, 14, and 21. Results indicated a significant reduction in blood glucose levels in the Aloe vera-treated group compared to the diabetic control (< 0.05). These findings suggest that Aloe vera has potential antihyperglycemic activity and could serve as a complementary therapy for diabetes management. Further research is needed to isolate active compounds and validate its efficacy in humans.

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Published

2025-07-22

Issue

Vol. 1 No. 1 (2025)

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Articles

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Copyright (c) 2025 Awal Noor Khan, Rashid Khan, Xue Li, Umar Khitab Saddozai, Haris Khan, Muhammad Wasim, Babar Ali, Muhammad Nadeem (Author)

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